Hydrogenation of amides catalyzed by a combined catalytic system of a Ru complex with a zinc salt
Addition of catalytic amounts of zinc salts facilitated the hydrogenation of amides catalyzed by a ruthenium complex bearing 2-(diphenylphosphino) ethanamine (L1). The combined catalytic system of the ruthenium complex [RuCl2(L1)2] with a zinc salt such as Zn(OCOCF 3)2 mediated hydrogenation of various amides under mild conditions to afford the corresponding primary alcohols.
Kita, Yusuke,Higuchi, Takafumi,Mashima, Kazushi
supporting information
p. 11211 - 11213
(2014/09/30)
Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists
N-(p-Alkoxy)benzoyl-2-methylindole-4-acetic acids 2r and 2s were identified as a new class of orally active prostaglandin D2 (PGD2) receptor antagonists. The process of discovering a series of N-(p-alkoxy)benzoyl-2-methylindole-4-ace