2H,15N-substituted nitroxides as sensitive probes for electron paramagnetic resonance imaging
Electron paramagnetic resonance imaging (EPRI) using nitroxides is an emergent imaging method for studying in vivo physiology, including O2 distribution in various tissues. Such imaging capabilities would allow O 2 mapping in tumors
Burks, Scott R.,Bakhshai, Justin,Makowsky, Mallory A.,Muralidharan, Sukumaran,Tsai, Pei,Rosen, Gerald M.,Kao, Joseph P. Y.
Targeted delivery of imaging probes for in vivo cellular imaging
The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.
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(2019/02/20)
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