- A 2,5-diamino -4,6-dihydroxy-pyridine synthesis method (by machine translation)
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The invention relates to a method for synthesis of compound, a 2,5? Diaminotriphenylamine? 4,6? Dihydroxybenzonic pyridine synthesis method. This method, in order to c diethyl adipic acid and hydrochloric acid guanidine is raw materials, through nitration, ammoniation reduction a series of reaction 2,5? Diaminotriphenylamine? 4,6? Dihydroxybenzonic pyridine, the method the production cost is cheap, mild reaction conditions, high yield. (by machine translation)
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Paragraph 0004; 0007
(2016/11/17)
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- Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution
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2-Amino-4,6-dichloro-5-nitropyrimidine is an intermediate required for the preparation of nitropyrimidines as inactivators of the DNA repairing protein MGMT. When attempting its synthesis, 2-amino-4,5,6-trichloropyrimidine is obtained instead, via unusual aromatic substitution of the nitro group in 2-amino-4-hydroxy-5-nitropyrimidin-6-one by chloride. The synthesis, the reactivity of 4,5,6-trichloropyrimidine and the efficient preparation of 2-amino-4,6-dichloro-5-nitropyrimidine are presented.
- Lopez, Sergio,McCabe, Thomas,Stanley McElhinney,McMurry, T. Brian H.,Rozas, Isabel
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scheme or table
p. 6022 - 6024
(2010/03/03)
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- Synthesis of a Naturally Occurring Dihydrohomopteridine Insect Metabolite, 6-Acetyl-2-amino-7,8-dihydro-9H-pyrimidodiazepin-4(3H)-one
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The naturally occurring dihydrohomopterin derivative 6-acetyl-2-amino-7,8-dihydro-9H-pyrimidodiazepin-4(3H)-one (1) has been synthesised from 1-amino-4,4-diethoxypentan-3-ol (10) and 2-amino-6-chloro-5-nitropyrimidin-4(3H)-one (3).A novel tricyclic intermediate, 2,2a-dihydroxy-2-methyl-6-nitro-1,2,2a,3,4,5-hexahydro-1,5,8,8b-tetra-aza-acenaphthylen-7-one was isolated.
- Boyle, Peter H.,Hughes, Enid M.,Khattab, Hassan A.,Lockhart, Ronan J.
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p. 2071 - 2077
(2007/10/02)
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- The Synthesis and Chlorination of Some Pyrimidin-4-ols Having 5-Nitrogen Functionality
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Syntheses of a number of pyrimidin-4-ols having 5-nitrogen functionality are described.Phosphorus oxychloride/diethylaniline chlorination of 6-amino-2-methylthio-5-nitropyrimidin-4-ol gave the corresponding 6-chloro derivative.However, 2-amino-6-methylthi
- Harnden, Michael R.,Hurst, Derek T.
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