- NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES
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The present invention relates to indole and pyrrolopyridine amide derivatives of formula (I) wherein R1, R 2, R 3, U, V, W, X, Y, Z and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
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Page/Page column 62
(2012/09/11)
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- A formal asymmetric synthesis of both enantiomers of the Erythrina alkaloid 3-demethoxyerythratidinone
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A formal asymmetric synthesis of both enantiomers of the Erythrina alkaloid 3-demethoxyerythratidinone is reported through the application of a highly functionalised lactam template as an N-acyliminium precursor.
- Allin, Steven M.,Streetley, Guy B.,Slater, Martin,James, Stella L.,Martin, William P.
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p. 5493 - 5496
(2007/10/05)
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- Facile and highly stereoselective synthesis of the tetracyclic erythrinane core
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A highly stereoselective synthesis of the tetracyclic core of the Erythrina alkaloids is reported through the application of a Meyers bicyclic lactam template.
- Allin, Steven M.,James, Stella L.,Elsegood, Mark R. J.,Martin, William P.
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p. 9464 - 9467
(2007/10/03)
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- Pyridine derivatives
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A pyridine derivative of the formula (I): STR1 wherein A is group of the following formulae: STR2 (R1 and R2 are each H, or protected or unprotected OH, R31, R41 and R42 are protected or unprotected h
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- Tetrahydroisoquinoline derivatives
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Compounds of the formula STR1 wherein R1 and R2 and each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or together form --OCH2 O-- or --OCH2 CH2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.
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