- A Stable, Non-aromatic, Adduct derived from 'ipso'-Nitration
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Nitration of N-propanamide (5) gave not only the expected products (6) and (7) but also the tricyclic adduct (8), the structure of which was confirmed by a single crystal X-ray analysis.
- Beeley, Nigel R. A.,Cremer, Gerard,Dorlhene, Alain,Mompon, Bernard,Pascard, Claudine,Tran Huu Dau, Elise
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- LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
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Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
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Paragraph 0445
(2013/03/26)
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- Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 2: Substituted benzo[a]cycloheptene derivatives
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Novel benzo[a]cycloheptene derivatives were prepared for the purpose of searching new neuropeptide Y-Y5 (NPY-Y5) receptor antagonists. The structure-activity relationships are described and compound 2o (FR226928) showed the most potent affinity for Y5 receptor of all we prepared and was found to have higher potency and better selectivity for Y5 over Y1 receptor affinities when compared with the known lead compound 1.
- Itani, Hiromichi,Ito, Harunobu,Sakata, Yoshihiko,Hatakeyama, Yoshifumi,Oohashi, Hiroko,Satoh, Yoshinari
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p. 757 - 761
(2007/10/03)
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- Propanolamine derivatives
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This invention relates to new propanolamine derivatives presented by the following formula [I]: wherein R1 is hydrogen or lower alkenyloxy, R2 is carboxy(lower)alkoxy or protected carboxy(lower)alkoxy, R3 is hydrogen or N-protective group, n is an integer of 1 or 2, and salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-pollakisuria activities, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
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