- Method for preparing french Nepal aldehydeaccompanies the Swiss Uygur A and method for the preparation of acid
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The invention provides a preparation method for Fanny aldehyde. The method comprises the step of performing an oxidizing reaction on farnesol under the effects of a catalyst and an oxidizing agent in an organic solvent to obtain the Fanny aldehyde, wherein the catalyst is Cu (copper) or a cupric compound. The invention further provides a preparation method for peretinoin. By the method disclosed by the invention, the metallic copper or the cupric compound are used as the catalyst to catalyze farnesol into the Fanny aldehyde, so that not only is the catalytic efficiency higher and the reaction conditions are mild, but also the purity and the yield of the prepared Fanny aldehyde are higher, and the Fanny aldehyde can be directly used for subsequently preparing the peretinoin without being purified. In addition, the preparation method for the Fanny aldehyde disclosed by the invention is green and pollution-free, and the industrial production can be realized. Experiment results prove that the yield of the Fanny aldehyde prepared by the method provided by the invention is more than 85%, and the purity is more than 95%; experiment results prove that the purity of a crude product of the peretinoin prepared by the method provided by the invention is more than 98%, and the purity is more than 99% after the crude product is recrystallized and refined.
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- METHOD FOR MANUFACTURING PHOSPHONOCROTONIC ACID DERIVATIVE
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Provided is a method of manufacturing a high quality phosphonocrotonic acid derivative. The present invention is a method of manufacturing a compound represented by the following Formula (3) by reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (2), which comprises a treatment process using an acid or base. [in the formula, R1 represents a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkenyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkynyl group that may be substituted by a C6-10 aryl group, or a C6-10 aryl group, R2 represents a hydrogen atom, or a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, R3 represents a C1-6 linear or branched alkyl group, a C6-10 aryl group, or a halogen atom, and X represents a halogen atom, and multiple R1s may be the same or different].
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Paragraph 0150-0152
(2014/03/24)
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- Method for preparing polyprenyl compounds
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A method for preparing a polyprenyl compound wherein an aldehyde represented by the following general formula [I]: [wherein n represents an integer of from 0 to 3] and a Wittig reagent represented by the following general formula [II]: [wherein each of R1 and R2 represents a group consisting of hydrocarbon] are reacted in a medium as a mixture of water and an organic solvent in the presence of a base, and further in the presence of a crown ether. Said method achieves an excellent selectivity and a high yield.
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- Method of purification of polyprenyl compounds
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A method for purification of a polyprenyl compound, which comprises the step of recrystallizing a polyprenyl compound, preferably (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid by using a solvent comprising an alcohol.
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- 3,7,11,15-Tetramethyl-2,4,6,10,14,-hexadecapentaendic acid
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A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an anticancer agent are also disclosed.
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- Method of treating cancerous and precancerous conditions
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An anti-cancer agent which comprises a polyprenvl compound having the formula (I): STR1 in which each of n and m is 0, 1 or 2, n+m is 0, 1 or 2, A is STR2 and B is STR3 in which R represents the hydroxyl group, a lower alkoxy group, or STR4 (wherein each of R1 and R2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or STR5 if n is 1, m is 0, A is STR6 and B is STR7
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- Conjugated polyprenylcarboxylic acids and their derivatives
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A conjugated polyprenylcarboxylic acid and its derivative having the formula: STR1 in which each of n and m is 0, 1 or 2, n+m is 1 or 2, A is STR2 and R is the hydroxyl group, a lower alkoxy group or STR3 wherein each of R1 and R2 represents the hydrogen atom, a lower alkyl group, or an aryl group; provided that R is STR4 if A is STR5 n is 1 and m is 0.
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- Method for treatment of inflammation
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A method for treatment of inflammation is disclosed which utilizes 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid represented by the following chemical structural formula: STR1 or a salt thereof, as the active ingredient.
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- Method of treating keratotic skin disease
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A compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed as a therapeutic agent for treatment of skin diseases with keratinization.
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