- A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol
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A biotransformation to produce (R)-Undecavertol has been developed and demonstrated on the pilot scale. The process is a racemic resolution using a highly (S)-selective alcohol dehydrogenase in the oxidative direction and an NAD(P)H oxidase for cofactor regeneration. Oxygen limitation is prevented by supplying pure oxygen, achieving a >400 g L–1 substrate concentration and a space-time yield of 14 g L–1 h–1 on the pilot scale and even up to 680 g L–1 and a space-time yield of 21 g L–1 h–1 on the lab scale. In three pilot-plant batches, more than 85 kg of (R)-Undecavertol was produced biocatalytically.
- Biermann, Marc,Brummund, Jan,Schmitges, Thomas,Schürmann, Martin,Vogel, Andreas
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supporting information
(2022/02/17)
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- Bio-catalysed synthesis of optically active Undecavertol enantiomers
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Two enantiomers of Undecavertol were prepared by enzymatic methods and their odour properties evaluated.
- Abate, Agnese,Brenna, Elisabetta,Fregosi, Ginevra
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p. 1997 - 1999
(2007/10/03)
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- Compounds having protected hydroxy groups
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The present invention relates to compounds with protected hydroxy groups of formula (I) These compounds are precursors for organoleptic agents, such as fragrances, and masking agents and for antimicrobial agents. When activated, the compounds of formula (I) are cleaved and form one or more organoleptic and/or antimicrobial compounds.
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- Beta-ketoester compounds
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The beta-ketoesters of formula I are useful as precursors for organoleptic compounds, especially for flavors, fragrances and masking agents and antimicrobial compounds.
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- Ketone precursors for organoleptic compounds
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The invention discloses ketones of formula I: wherein, Y is an optionally substituted alkyl, cycloalkyl, or cycloalkylalkyl, wherein each alkyl group is straight or branched and each alkyl and cycloalkyl group is saturated or unsaturated; R1is hydrogen or a C1-6alkyl group that is substituted, saturated or unsaturated, straight or branched; A is a chromophoric substituted aromatic ring or ring system; n is an integer; and with the proviso that formula I is not 2-ethoxy-1-phenyl-ethanone. These compositions are useful for the delivery of organoleptic compounds, especially of flavors, fragrances, masking agents and antimicrobial compounds.
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- Odorant and/or flavoring substances
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The invention is concerned with compounds of the formula: STR1 wherein one of the symbols R1, R2 and R3 stands for methyl or ethyl and the others stand for hydrogen and R4 signifies hydrogen or methyl, with the proviso that R4 represents hydrogen when R1 and R2 both represent hydrogen and R3 represents methyl and their use as odorants and flavorants.
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