- RuV-Acylimido Intermediate in [RuIV(Por)Cl2]-Catalyzed C–N Bond Formation: Spectroscopic Characterization, Reactivity, and Catalytic Reactions
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Metal-catalyzed C?N bond formation reactions via acylnitrene transfer have recently attracted much attention, but direct detection of the proposed acylnitrenoid/acylimido M(NCOR) (R=aryl or alkyl) species in these reactions poses a formidable challenge. H
- Che, Chi-Ming,Hong, Dan-Yan,Huang, Jie-Sheng,Law, Siu-Man,Liu, Yungen,Lo, Vanessa Kar-Yan,Toy, Patrick H.,Wu, Liangliang
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supporting information
p. 18619 - 18629
(2021/06/09)
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- Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions
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An efficient synthesis of α-amidoketone derivatives through the cascade reactions of carboxylic acids with vinyl azides is presented. Compared with literature protocols, notable features of this new method include catalyst-free conditions, broad substrate scope, good tolerance of a wide range of functional groups, and high efficiency. In addition, the synthetic potential of this method as a tool for late-stage modification was convincingly manifested by its application in the structural elaborations of a number of carboxylic acid drug molecules.
- Gao, Cai,Zhou, Qianting,Yang, Li,Zhang, Xinying,Fan, Xuesen
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p. 13710 - 13720
(2020/11/13)
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- Synthesis method of alpha-acylamino ketone compound
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The invention discloses a synthesis method of an alpha-acylamino ketone compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixingan alkenyl azide compound 1, a carboxylic acid compound 2 and an organic solvent, and heating to react to obtain the alpha-acylamino ketone compound 3. Compared with the prior art, the method has thefollowing advantages: (1) the synthesis process is simple and efficient, no catalyst is needed in the whole process, and the alpha-acylamino ketone compound can be obtained with high yield by dissolving the alkenyl azide compound and the carboxylic acid compound in the solvent and stirring; (2) raw materials are cheap and easy to obtain, reaction conditions are mild, and operation is simple; (3) the substrate is wide in application range and can be used for modifying drug molecules; and (4) the atom economy is high, and the requirements of green chemistry are met.
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Paragraph 0027-0029; 0030-0032; 0078
(2020/12/08)
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- Fischer synthesis of 3-(N-acylamino)-2-phenylindoles
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Phenylhydrazones were obtained by the reaction of phenylhydrazine with ω-(N-acylamino)-acetophenones and were converted into 3-(N-acylamino)indoles by the Fischer cyclizaction.
- Przheval'Skii,Skvortsova,Magedov
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p. 1055 - 1061
(2007/10/03)
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- Water-binding solid scintillators: Synthesis, emission properties, and tests in 3H and 14C counting
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Spectral and time-resolved fluorescence properties as well as relative fluorescence quantum yields of carbodiimide derivatives of 2,5-diphenyloxazole (PPO) (prepared by H2S elimination from the corresponding thioureas), of some intermediates in the preparation, and of several other PPO derivatives were investigated in solution and in the solid state to test their suitability as solid scintillators. The carbodiimides reacted slowly with water under acidic conditions to yield ureas. These systems were compared with solid mixtures of other PPO derivatives with sodium sulfate as a drying agent, as chemically water-binding solid scintillators in 3H and 14C counting. Both the chemically and the absorptive water-binding scintillators proved capable of counting 3H and 14C decay, and open a way to the counting of aqueous samples by solid scintillators without a drying step.
- Meyer, Hans-Joachim,Wolff, Thomas
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p. 2809 - 2817
(2007/10/03)
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- Synthesis and hypolipidemic activities of 5-thienyl-4-oxazoleacetic acid derivatives
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A series of 2,5-disubstituted 4-oxazoleacetic acid derivatives was synthesized and evaluated for hypolipidemic activity. Among them, those with a thienyl group at C-5 of the oxazole ring exerted highly potent hypolipidemic effects in rats. 2-(4-Fluorophen
- Moriya,Takabe,Maeda,Matsumoto,Takashima,Takeyama
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p. 333 - 341
(2007/10/02)
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