Synthesis of novel N-(4-ethoxyphenyl) azetidin-2-ones and their oxidative N-deprotection by ceric ammonium nitrate
It is shown that the N-(p-ethoxyphenyl) group on β-lactams can be oxidatively removed by ceric ammonium nitrate in good yield. Fourteen new N-(p-ethoxyphenyl)-2-azetidinones 8a-n were synthesized through standard [2+2] ketene-imine cycloadditions (Staudinger reaction). Treatment of these compounds with ceric ammonium nitrate yielded the N-dearylated 2-azetidinones 9a-n in good to excellent yields. The effects of solvent, molar equiv of CAN and different temperatures have been investigated and optimum conditions were established.
Jarrahpour, Aliasghar,Zarei, Maaroof
p. 2364 - 2379
(2008/02/14)
Studies on Schiff Bases of Veratraldehyde
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Rai, Mangat,Kaur, Baljit,Dhir, B. S.
p. 416 - 417
(2007/10/02)
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