- Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2
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The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unprecedented in human history. As a major structural protein, nucleocapsid protein (NPro) is critical to the replication of SARS-CoV-2. In this work, 17 NPro-
- Cai, Jie-Yun,Chen, Duo-Zhi,Ding, Xiao,Fan, Shi-Rui,Hao, Xiao-Jiang,Jing, Chen-Xu,Long, Xin-Yan,Luo, Rong-hua,Ren, Juan,Ruan, Ting,Wang, Yi-Ting,Yang, Bi-Juan,Yang, Lian,Zhang, Xin-Fang,Zheng, Yong-Tang
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supporting information
(2021/11/11)
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- A versatile approach to 1-oxo-, 1-oxo-3,4-dihydro- and 1,3,4-trioxo isoquinoline alkaloids and first total synthesis of the dimeric 1-oxoisoquinoline alkaloids berbanine and berbidine
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We have worked out a very short approach to 1-oxoisoquinoline alkaloids starting from readily available 2-bromobenzamides utilizing a 2-ethoxyvinylboronate as a C2 building block for introduction of the C-3,C-4 unit of the isoquinoline core. TF
- Schütz, Ramona,Schmidt, Sandra,Bracher, Franz
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- COMPOUND FOR TREATMENT OR PREVENTION OF OBESITY OR DISEASES RELATED TO OBESITY, AND APPLICATION THEREOF
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A compound for treatment or prevention of obesity or diseases related to obesity, and an application thereof. Specifically, provided are a compound as represented by formula I, or a pharmaceutically-acceptable salt thereof, and a pharmaceutical compositio
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Paragraph 0272
(2020/08/09)
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- A combined pathway for the synthesis of nitidine family alkaloids
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Three related alkaloids, oxynitidine, nitidine and 5,6-dihydronitidine, have been afforded by the new synthetic protocols. In this approach, the Ni-catalyzed annulation reaction is indicated as the key step to construct the isoquinolinone core structure. The subsequent transformations lead to the target alkaloids.
- Pallikonda, Gangaram,Hsieh, Chang-Yu,Su, Haw-Lih,Hsieh, Jen-Chieh
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p. 5399 - 5407
(2019/11/03)
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- Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists
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Phenanthridine derivativeHLY78 has previously been identified as the first Wnt/β-catenin signalling pathway agonist that targets the DAX domain of axin. However, due to the relatively weak activation on the Wnt/β-catenin signalling pathway, HLY78 is insuf
- Chen, Duo-zhi,Yang, Bi-juan,He, Xiao-li,Fan, Shi-rui,Cai, Jie-yun,Jing, Chen-xu,Zhang, Heng,Zhang, Yu,Li, Lin,Hao, Xiao-jiang
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p. 285 - 294
(2018/12/11)
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- Phenanthridine Derivatives, Preparation Methods and Uses Thereof
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The present invention relates to the pharmaceutical field, in particular to a phenanthridine derivative as shown in general formula (1) a pharmaceutical composition comprising the derivative, its preparation method, and its uses in manufacture of a medica
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Paragraph 0126
(2016/04/19)
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- Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway
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The synthesis of 4-ethyl-5-methyl-5,6-dihydro-phenanthridine-8,9-diol as the key intermediate of a series of potent Wnt signalling pathway agonists is reported. This synthesis features a consecutive aryl-aryl and N-aryl coupling, leading to 4-ethyl-5-meth
- Jing, Chen-Xu,Cai, Jie-Yun,Zhang, Yu,Chen, Duo-Zhi,Hao, Xiao-Jiang
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p. 247 - 250
(2015/06/02)
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- Studies on SRN1 Reactions. Part 6: Synthesis of 3-Methyl Derivatives of the Alkaloids Thalactamine, Doryanine, and 6,7-Dimethoxy-N-methyl-1(2H)-isoquinolone
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A new, short synthesis of the 3-methyl derivatives (3a-c) of the alkaloids thalactamine, doryanine, and 6,7-dimethoxy-N-methyl-1(2H)-isoquinolone, based upon our previous SRN1 synthesis of isocarbostryril systems, is reported.
- Beugelmans, Rene,Ginsburg, Helene,Bois-Choussy, Michele
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p. 1149 - 1152
(2007/10/02)
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