cas 82964-04-3, Tolrestat | Articles data ｜lookchem

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82964-04-3

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USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS
The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
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(2008/06/13)

N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylgl ycine (Tolrestat), a potent, orally active aldose reductase inhibitor
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Sestanj,Bellini,Fung,Abraham,Treasurywala,Humber,Simard-Duquesne,Dvornik
p. 255 - 256
(2007/10/02)

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Chemical Properties

Melting Point: 164-165°
Boiling Point: 498.1 °C at 760 mmHg
Flash Point:255 °C
Density: 1.399 g/cm³
Solubility:Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
Storage Temp.:2-8°C
Vapor Pressure: 9.69E-11mmHg at 25°C
Refractive Index: 1.601
PKA: 3.49±0.10(Predicted)
PSA: 81.86000
LogP: 3.55910

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