cas 832710-65-3, 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) | Articles data ｜lookchem

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832710-65-3

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INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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Page/Page column 56

(2016/11/07)

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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Page/Page column 106

(2015/02/25)

HETEROCYCLIC COMPOUND
An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.
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Paragraph 0335

(2015/11/09)

More Articles about upstream products of 832710-65-3

268550-48-7
1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

More Articles about downstream products of 832710-65-3

Chemical Properties

Boiling Point: 383.2oC at 760 mmHg
Flash Point:185.5oC
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 3.01E-06mmHg at 25°C
PSA: 41.13000
LogP: 1.33570

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