- Iron Promoted Ring Opening and Ring Closing Cascade (ROCC) Reaction of Ortho-Carboxy-Isoxazoles Leading to Isoindolinone Derivatives
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An efficient and convenient route for the synthesis of various functionalized 3-alkylidene isoindolin-1-ones is presented. The synthesis involves the ring opening and ring closing cascade (ROCC) reaction of ortho-carboxy-isoxazole using Fe/NH4Cl. This is the first report for the synthesis of 3-alkylidene isoindolin-1-one using Fe/NH4Cl.
- Gudipati, Ramakrishna,Jayaram, Vankudoth,Raghavulu, Karri,Bhoot, Dinesh,Basavaiah, Keloth,Yennam, Satyanarayana,Behera, Manoranjan
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p. 5127 - 5134
(2021/10/19)
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- Aromatic Carbonylation Regio-Controlled by Oxazole and Isoxazole Rings, Novel Route to Heterocycle-Substituted o-Benzoates
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3,5-Diphenylisoxazole and 2,5-diphenyloxazole were regioselectively carbonylated under an atmosphere of carbon monoxide after the formation of arylpalladium(II) intermediates, to give bioactive o-benzoates substituted by isoxazole and oxazole rings in goo
- Sakakibara, Tsutomu,Kume, Takashi,Ohyabu, Takahiro,Hase, Tsunao
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p. 1694 - 1697
(2007/10/02)
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- Nitrile Oxide Cycloaddtion Routes to 2-(Isoxazolyl)benzoates and 2-(1,2,4-Oxadiazol-3-yl)benzoates
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Cycloaddition of aromatic nitrile oxides to methyl o-vinylbenzoate produced methyl 2-(3-aryl-2-isoxazolin-5-yl)benzoates; the isoxazolines were converted to methyl 2-(3-arylisoxazol-5-yl)benzoates.Reaction of the nitrile oxide from o-methoxycarbonylbenzohydroximinoyl chloride (11) with phenylacetylene, styrenes, and aromatic nitriles resulted in methyl 2-(5-phenylisoxazol-3-yl)benzoate, methyl 2-(5-aryl-2-isoxazolin-3-yl)benzoates (15) and methyl 2-(5-aryl-1,2,4-oxadiazol-3-yl)benzoates, respectively.The isoxazolines 15 were converted to the corresponding isoxazoles 16.
- Howe, Robert K.,Schleppnik, Frances M.
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p. 721 - 726
(2007/10/02)
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- Aryl-3-isoxazole benzoates as plant growth regulants and herbicides
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2-(5-Aryl or substituted aryl-3-isoxazolyl) benzoic acids or benzoates, e.g., 2-[5-[3-(trifluoromethyl)phenyl]-3-isoxazolyl] benzoic acid, and to their method of use as herbicides and plant growth regulants as well as to agricultural chemical compositions
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