cas 84000-11-3, Fmoc-N-methyl-L-valine | Articles data

Articles about 84000-11-3Total 8 be found

A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods
[2S,3S-Hmp]-Aureobasidin L 2 has been successfully synthesised through a combination of solution- and solid-phase peptide synthesis. All of the Fmoc-protected residues including a depsidipeptide, Fmoc-MeVal-Hmp-OH, were prepared in solution phase. Chain e
Maharani, Rani,Brownlee, Robert T.C.,Hughes, Andrew B.,Abbott, Belinda M.
p. 2351 - 2358
(2014/04/03)

Fluorenylmethoxycarbonyl-N-methylamino acids synthesized in a flow tube-in-tube reactor with a liquid-liquid semipermeable membrane
Both steps of the N-methylation of 9-fluorenylmethoxycarbonyl (Fmoc) amino acids were carried out in a microstructured tube-in-tube reactor equipped with a semipermeable Teflon AF 2400 membrane as the inner tubing. In the first step, gaseous formaldehyde
Buba, Annette E.,Koch, Stefan,Kunz, Horst,Loewe, Holger
p. 4509 - 4513
(2013/07/26)

A preparation of N-Fmoc-N-methyl-α-amino acids and N-nosyl-N-methyl-α-amino acids
A convenient route for the synthesis of lipophilic N-Fmoc-N-methyl-α- amino acids and N-nosyl-N-methyl-α-amino acids, interesting building blocks to be used for the preparation of N-methylated peptides, is presented. Both nosyl- and Fmoc-protected monomer
Di Gioia, Maria Luisa,Leggio, Antonella,Liguori, Angelo,Perri, Francesca,Siciliano, Carlo,Viscomi, Maria Caterina
scheme or table
p. 133 - 143
(2010/08/19)

An efficient preparation of N-Methyl-α-amino acids from N-Nosyl-α-amino acid phenacyl esters
Chemical Equation Presented In this paper we describe a simple and efficient solution-phase synthesis of N-methyl-TV-nosyl-α-amino acids and N-Fmoc-N-methyl-α-amino acids. This represents a very important application in peptide synthesis to obtain N-methylated peptides in both solution and solid phase. The developed methodology involves the use of N-nosyl-α-amino acids with the carboxyl function protected as a phenacyl ester and the methylating reagent diazomethane. An important aspect of this synthetic strategy is the possibility to selectively deprotect the carboxyl function or alternatively both amino and carboxyl moieties by using the same reagent with a different molar excess and under mild conditions. Furthermore, the adopted procedure keeps unchanged the acid-sensitive side chain protecting groups used in Fmoc-based synthetic strategies.
Leggio, Antonella,Belsito, Emilia Lucia,De Marco, Rosaria,Liguori, Angelo,Perri, Francesca,Viscomi, Maria Caterina
supporting information; experimental part
p. 1386 - 1392
(2010/06/11)

Solid-phase synthesis of N-nosyl- and N-Fmoc-N-methyl-α-amino acids
(Chemical Equation Presented) We report here a convenient and simple solid-phase synthesis of N-nosyl-N-methyl-α-amino acids and N-Fmoc-N-methyl-α-amino acids, important building blocks for the synthesis of conformationally restricted and protease-resista
Di Gioia, Maria Luisa,Leggio, Antonella,Liguori, Angelo,Perri, Francesca
p. 3723 - 3728
(2008/02/05)

An improved synthesis of Fmoc-N-methyl-α-amino acids
A highly efficient and environmentally more benign synthesis of Fmoc-N-methyl-α-amino acids from the corresponding Fmoc-amino acid, via intermediate 5-oxazolidinones, has been developed by using Lewis acid catalysis for the reductive opening of the oxazol
Zhang, Suode,Govender, Thavendran,Norstroem, Thomas,Arvidsson, Per I.
p. 6918 - 6920
(2007/10/03)

Solid phase synthesis of Fmoc N-methyl amino acids: Application of the Fukuyama amine synthesis
N-Methyl amino acids and their Fmoc derivatives are synthesized in high yield and purity on solid support using the Fukuyama amine synthesis protocol.
Yang, Lihu,Chiu, Kuenley
p. 7307 - 7310
(2007/10/03)

Synthesis of 9-Fluorenylmethyloxycarbonyl-Protected N-Alkyl Amino Acids by Reduction of Oxazolidinones
A new two-step synthesis of Fmoc-protected N-alkyl amino acids has been developed.The first step involves acid-catalyzed condensation of an Fmoc-protected amino acid with an aldehyde to form an oxazolidinone.This intermediate is then reduced with triethyl
Freidinger, Roger M.,Hinkle, Jeffery S.,Perlow, Debra S.,Arison, Byron H.
p. 77 - 81
(2007/10/02)