- Isoxazole carboxamide derivatives as ghrelin receptor modulators
-
The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
- -
-
Page/Page column 19
(2010/11/08)
-
- Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists
-
A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described.
- Xin, Zhili,Zhao, Hongyu,Serby, Michael D.,Liu, Bo,Schaefer, Verlyn G.,Falls, Douglas H.,Kaszubska, Wiweka,Colins, Christine A.,Sham, Hing L.,Liu, Gang
-
p. 1201 - 1204
(2007/10/03)
-