Construction of quaternary carbon stereocentres: Catalytic enantioselective allylation assisted by a bimetallic catalytic system
The asymmetric allylic alkylation of prochiral aryl cyano esters has been carried out in the presence of a bi-component catalytic system containing a palladium and a rhodium complex modified by phosphorus containing chiral auxiliaries. The allyl derivativ
Acetone cyanohydrin as a source of HCN in the Cu-catalyzed hydrocyanation of α-aryl diazoacetates
A procedure for the Cu-catalyzed hydrocyanation of α-aryl diazoesters has been developed using acetone cyanohydrin as a source of hydrogen cyanide (HCN). It was found that the addition of trimethylsilyl cyanide (TMSCN) significantly accelerates the conversion presumably by delivering free cyanide ion in situ, thus producing various types of α-aryl cyanoacetates in high yields under mild conditions.
Park, Eun Ju,Lee, Seungeon,Chang, Sukbok
supporting information; experimental part
p. 2760 - 2762
(2010/07/08)
Highly selective preparation of a chiral quaternary allyl aryl piperidinedione by palladium-catalyzed asymmetric allylation under solid-liquid phase-transfer catalysis
The combination of a chiral palladium catalyst and a solid-liquid phase-transfer catalyst provides an effective method for the chemo- and enantioselective preparation of the chiral quaternary center of an allyl aryl piperidinedione. Wiley-VCH Verlag GmbH
Catalytic enantioselective allylation at the activated benzylic position of prochiral aryl cyano esters: Access to quaternary stereogenic centers
Palladium catalyzed asymmetric allylic alkylation of prochiral aryl cyano esters has been carried out in the presence of various chiral ligands. The base and additives have been varied and allowed to produce the allyl derivative presenting a highly functi