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The present invention discloses a novel 2-anilino-6-methylbenzothiazole derivative having the chemical formula (I), or a pharmaceutically acceptable salt, wherein the definition of each substituent is defined in the patent description and claims. This invention also discloses a method for preparing these derivatives as well as preparation of pharmaceutical chemicals for applications in treating hepatitis C.
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Paragraph 0052; 0054; 0070
(2017/03/08)
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- Copper-catalyzed synthesis of 2-aminobenzothiazoles from carbodiimide and sodium hydrosulfide
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An efficient copper-catalyzed method for the synthesis of a variety of 2-aminobenzothiazoles has been developed. The reaction proceeded from carbodiimide and sodium hydrosulfide via a tandem reaction in the presence of copper(ii) trifluoromethanesulfonate to afford the corresponding 2-aminobenzothiazole derivatives in good to perfect yields. This journal is the Partner Organisations 2014.
- Zeng, Weilan,Dang, Pan,Zhang, Xiaoyun,Liang, Yun,Peng, Caiyun
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p. 31003 - 31006
(2014/08/05)
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- Copper/N,N,N',N'-tetramethylethylenediamine-catalyzed synthesis of N-substituted benzoheterocycles via C-S cross-coupling at ambient temperature in water
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Copper/N,N,N',N'-tetramethylethylenediamine (Cu/TMEDA)-catalyzed ambient temperature tandem reactions of isothiocyanates with 2-iodophenols or 2-iodoanilines in water without the protection of an inert atmosphere are described, which provide a simple, rapid, environmental method for the synthesis of a variety of 2-iminobenzo-1, 3- oxathioles and 2-aminobenzothiazoles in good yields. More important, the present reaction process needs only low amounts of copper catalyst (1mol%) and can yield the products on a gram scale.
- Zhao, Na,Liu, Liang,Wang, Fei,Li, Jia,Zhang, Wu
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supporting information
p. 2575 - 2579
(2014/09/17)
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- Ligand- and solvent-free synthesis of 2-aminobenzothiazoles by copper-catalyzed tandem reaction of 2-haloanilines with isothiocyanates
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We report an environmentally friendly, efficient and practical method for the synthesis of 2-aminobenzothiazoles by a copper(II)-catalyzed tandem reaction of 2-haloanilines with isothiocyanates under ligand- and solvent-free conditions in air. The developed methodology conforms to the principles of 'green chemistry' and addresses the shortage of such methods for the synthesis of 2-aminobenzothiazoles. The reaction is quite general and generates a variety of 2-aminobenzothiazoles in good to excellent yields. Copyright
- Yao, Ruiya,Liu, Haiyi,Wu, Yichao,Cai, Mingzhong
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p. 109 - 113
(2013/03/13)
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- 1,10-Phenanthroline-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates in water
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The 1,10-phenanthroline-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water is described, which provides an environmentally benign, efficient and simple route for the preparation of 2-aminobenzothiazoles. The present tandem process shows broad substrate scope in the absence of transition metals and phase-transfer catalysts. Copyright
- Zhang, Wu,Yue, Yun,Yu, Dan,Song, Lei,Xu, Yang-Yang,Tian, Yu-Jie,Guo, Yu-Jun
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supporting information
p. 2283 - 2287
(2012/11/07)
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- A practical synthesis of 2-aminobenzothiazoles via the tandem reactions of 2-haloanilines with isothiocyanates catalyzed by immobilization of copper in MCM-41
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The heterogeneous tandem reactions of 2-haloanilines with isothiocyanates were achieved in DMSO using Et3N as base at 80 °C in the presence of a 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-CuSO4], yielding a variety of 2- aminobenzothiazoles in good to excellent yields. This heterogeneous copper catalyst exhibited higher activity than CuSO4 and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decreases in activity.
- Xiao, Ruian,Hao, Wenyan,Ai, Jinting,Cai, Ming-Zhong
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experimental part
p. 44 - 50
(2012/04/17)
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- DDQ-promoted C-S bond formation: Synthesis of 2-aminobenzothiazole derivatives under transition-metal-, ligand-, and base-free conditions
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A transition-metal-free method for the intramolecular S-arylation of o-halobenzothiaoureas via DDQ-mediated leading to the 2-aminobenzothiazole derivatives is reported. The reactions are performed at room temperature under ligand- and base-free conditions with good to excellent yields. Georg Thieme Verlag Stuttgart · New York.
- Wang, Rui,Yang, Wen-Juan,Yue, Liang,Pan, Wei,Zeng, Hong-Yao
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experimental part
p. 1643 - 1648
(2012/08/07)
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- Merrifield resin supported phenanthroline-Cu(I): A highly efficient and recyclable catalyst for the synthesis of 2-aminobenzothiazoles via the reaction of 2-haloanilines with isothiocyanates
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A novel Merrifield resin supported phenanthroline-Cu(I) complex has been developed and used as a highly efficient and recyclable catalyst in the reaction of 2-halobenzenamines with isothiocyanates for the synthesis of 2-aminobenzothiazoles. The reactions
- Yang, Jin,Li, Pinhua,Wang, Lei
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experimental part
p. 5543 - 5549
(2011/08/06)
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- Synthesis of N-substituted-2-Aminobenzothiazoles by ligand-Free copper(I)-Catalyzed cross-Coupling reaction of 2-haloanilines with isothiocyanates www.eurjoc.org
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A novel and efficient formation of N-substituted-2-aminobenzothiazoles by a ligand-free copper(I)-catalyzed one-pot cascade process was developed. A variety of isothiocyanates coupled with 2-iodoanilines to give N-substituted-2-amino-benzothiazoles in mod
- Shen, Guodong,Lv, Xin,Bao, Weiliang
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scheme or table
p. 5897 - 5901
(2010/03/01)
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