Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides
The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.
Mikhailovskaya,Vasilevsky
experimental part
p. 632 - 636
(2011/02/17)
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