Provided herein are methods of treating liposarcoma in a subject, the method comprising administering to the subject a therapeutically effective amount of an Hsp90 inhibitor.
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Page/Page column 49
(2010/12/18)
Hydroquinone Ansamycin Formulations
Pharmaceutical compositions of hydroquinone geldanamycin analogs, and uses of such compositions, are provided.
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Page/Page column 8-9
(2008/12/04)
ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS FOR THE TREATMENT OF CANCER
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer ( formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)--ammonium hydroquinone ansamycin analog.
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(2010/02/12)
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