cas 86-39-5, 2-Chlorothioxanthone | Articles data

Articles about 86-39-5Total 22 be found

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Muren,Bloom
p. 14,16
(1970)
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Oxidation of chlorprothixene with potassium permanganate
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Tammilehto
p. 524 - 524
(1980)
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Oxidation of chlorprothixene with ceric sulphate.
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Agarwal,Blake
p. 556 - 556
(1969)
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Catalyst-Controlled Stereoselective Barton–Kellogg Olefination
Overcrowded alkenes are expeditiously prepared by the versatile Barton–Kellogg olefination and have remarkable applications as functional molecules owing to their unique stereochemical features. The induced stereodynamics thereby enable the controlled motion of molecular switches and motors, while the high configurational stability prevents undesired isomeric scrambling. Bistricyclic aromatic enes are prototypical overcrowded alkenes with outstanding stereochemical properties, but their stereocontrolled preparation was thus far only feasible in stereospecific reactions and with chiral auxiliaries. Herein we report that direct catalyst control is achieved by a stereoselective Barton–Kellogg olefination with enantio- and diastereocontrol for various bistricyclic aromatic enes. Using Rh2(S-PTAD)4 as catalyst, several diazo compounds were selectively coupled with a thioketone to give one of the four anti-folded overcrowded alkene stereoisomers upon reduction. Complete stereodivergence was reached by catalyst control in combination with distinct thiirane reductions to provide all four stereoisomers with e.r. values of up to 99:1. We envision that this strategy will enable the synthesis of topologically unique overcrowded alkenes for functional materials, catalysis, energy- and electron transfer, and bioactive compounds.
Schmidt, Tanno A.,Sparr, Christof
supporting information
p. 23911 - 23916
(2021/10/08)

COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
The present invention relates to a compound for an organic electronic element. To the present invention, an organic electronic element having high luminous efficiency, low driving voltage, and high heat resistance can be provided, and color purity and lifetime of the organic electronic element can be improved.
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Paragraph 0360-0361; 0364-0365

(2021/03/23)

Ultraviolet-light-induced aerobic oxidation of benzylic C(sp3)-H of alkylarenes under catalyst- and additive-free conditions
A mild and efficient system has been discovered for the synthesis of α-aryl carbonyl compounds via oxidation of benzylic C–H to C[dbnd]O bonds. This ultraviolet-light-mediated oxygenation reaction exhibited excellent substrate scope including various xanthenes, thioxanthenes and 9, 10-dihydroacridines and afforded the corresponding ketones with good to excellent yields under catalyst- and additive-free conditions at room temperature.
Zhou, Jiacheng,Li, Meichao,Li, Tianci,Li, Chunmei,Hu, Xinquan,Jin, Liqun,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu
(2021/02/01)

Novel synthesis method of chlorolucanthone
The invention discloses a novel synthesis method of chlorolucanthone, and belongs to the technical field of chemical engineering. The method comprises the following steps: firstly, adding a sodium hydrosulfide solution into a hydrogen sulfide generator, then dropwise adding an acid into the hydrogen sulfide generator, and guiding generated gas into a preheated pipeline reactor; pumping preheated p-dichlorobenzene into the pipeline reactor, reacting the p-dichlorobenzene with hydrogen sulfide gas, cooling a reaction product to obtain liquid and gas, and rectifying and purifying the liquid to obtain mercaptochlorobenzene; secondly, adding a reaction solvent and an alkali into a flask, stirring, adding mercaptochlorobenzene and o-chlorobenzoic acid, carrying out a reflux reaction, and carrying out aftertreatment after the reaction is finished so as to obtain an intermediate 2-carboxyl-4'-chlorodiphenyl sulfide; and finally, adding 2-carboxyl-4'-chlorodiphenyl sulfide into concentrated sulfuric acid, carrying out an intramolecular cyclization dehydration reaction, and purifying after the reaction is ended so as to obtain the target product. The method disclosed by the invention is simple and convenient to operate, mild in reaction condition, clean and environment-friendly, and high in product yield and purity.
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Paragraph 0022; 0029; 0033-0034; 0038-0039; 0043-0044; 0048

(2020/10/21)

A metal-free heterogeneous photocatalyst for the selective oxidative cleavage of CC bonds in aryl olefins: via harvesting direct solar energy
Selective cleavage of CC bonds is highly important for the synthesis of carbonyl containing fine chemicals and pharmaceuticals. Novel methodologies such as ozonolysis reactions, Lemieux-Johnson oxidation reaction etc. already exist. Parallel to these, catalytic methods using homogeneous catalysts also have been discovered. Considering the various advantages of heterogeneous catalysts such as recyclability and stability, couple of transition metal-based heterogeneous catalysts have been applied for this reaction. However, the pharmaceutical industries prefer to use metal-free catalysts (especially transition metal-free) to avoid further leaching in the final products. This is for sure a big challenge to an organic chemist and to the pharmaceutical industries. To make this feasible, a mild and efficient protocol has been developed using polymeric carbon nitrides (PCN) as metal-free heterogeneous photocatalysts to convert various olefins into the corresponding carbonyls. Later, this catalyst has been applied in the gram scale synthesis of pharmaceutical drugs using direct solar energy. Detailed mechanistic studies revealed the actual role of oxygen, the catalyst, and the light source.
Das, Shoubhik,Hatami, Nareh,Jooss, Christian,Lange, Niklas Simon,Ronge, Emanuel,Schilling, Waldemar,Zhang, Yu
supporting information
p. 4516 - 4522
(2020/08/10)

Ultraviolet light promoted synthesis method of thioxanthone compounds
The invention discloses an ultraviolet light promoted synthesis method of a thioxanthone compound. The preparation method comprises the following steps: carrying out a reaction in 1,2-dichloroethane at normal temperature under the condition of 380-385 nm ultraviolet irradiation by taking a thioxanthone compound as a reaction substrate and taking oxygen in air as an oxidizing agent, and after the reaction is finished, carrying out separation treatment to obtain the thioxanthone compound. According to the synthesis method disclosed by the invention, the traditional heating reaction is replaced by an illumination reaction, so that energy sources can be saved, and any catalyst is not used.
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Paragraph 0029-0030

(2020/06/02)

A medicinal composition for combining thioxanthone paclitaxel and STAT3 inhibitor
A medicinal composition for combining thioxanthone paclitaxel and STAT3 inhibitor, comprising an active ingredient and a pharmaceutically acceptable adjuvant, characterized in that the active ingredient is composed of paclitaxel and a STAT3 inhibitor represented by formula (I) (shown in the description), and the mass ratio of the paclitaxel to the STAT3 inhibitor represented by formula (I) in theactive ingredient is (0.18 to 0.32): 1. The compound has an effect on MDA having persistently activated STAT3 activity-MB-468 cell, DU-145 cells had good inhibitory effect.
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Paragraph 0075; 0076; 0077; 0078

(2019/01/23)

STAT3 inhibitors and application thereof
The invention belongs to the field of medical chemistry, relates to STAT3 inhibitors and an application thereof and particularly relates to compounds for inhibiting the signal transduction and transcription activator-3, a pharmaceutical composition containing the compound and a use of the compounds or the pharmaceutical composition as cancer treatment drugs. The compounds can well inhibit MDA-MB-468 cells and DU-145 cells with sustained STAT3 activity.
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Paragraph 0139-0143

(2019/01/20)

Thioxanthone Signal Transducer and Activator of Transcription-3 (STAT3) inhibitor and application thereof
The invention belongs to the field of medical chemistry, and relates to a thioxanthone Signal Transducer and Activator of Transcription-3 (STAT3) inhibitor as shown by a formula (I) and application thereof, in particular to a compound with STAT3 inhibiting effects, a drug composition containing the compound, and the application of the compound or the drug composition as a cancer treatment drug. The compound has remarkable inhibiting effects on MDA-MB-468 cells and DU-145 cells with continuously activated STAT3 activity. (The formula is as shown in the description).
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Paragraph 0074; 0075; 0076; 0077; 0078

(2019/02/27)

Thioxanthone STAT3 (signal transducer and activator of transcription-3) inhibitor maleate crystal form A and application thereof
The invention belongs to the field of medical chemistry and relates to a thioxanthone STAT3 (signal transducer and activator of transcription-3) inhibitor shown as formula (I) and an application thereof, in particular to compounds with a STAT3 inhibition function, pharmaceutical composition containing the compounds and an application of the compounds or the pharmaceutical composition as cancer treatment drugs. The compounds have good inhibition functions on MDA-MB-468 cells and DU-145 cells with continuously activated STAT3 activity.
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Paragraph 0078-0082

(2019/09/17)

Visible-Light-Induced Aerobic Oxidation of Benzylic C(sp 3)-H of Alkylarenes Promoted by DDQ, tert -Butyl Nitrite, and Acetic Acid
A visible-light photocatalytic aerobic oxidation of benzylic C(sp 3)-H bonds proceeded in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tert -butyl nitrite, and acetic acid. Advantages of this aerobic oxidation method include its relatively mild conditions, the use of visible-light irradiation instead of conventional thermal methods, the use of a low catalyst loading, and the ability to oxidize a range of alkylarenes, including xanthenes, thioxanthenes, and 9,10-dihydroacridines, to the corresponding ketones in excellent yields.
Pan, Decheng,Wang, Yiqing,Li, Meichao,Hu, Xinquan,Sun, Nan,Jin, Liqun,Hu, Baoxiang,Shen, Zhenlu
p. 218 - 224
(2019/01/14)

A sulfur mixed anthracene compound photocatalytic oxidation synthesis method (by machine translation)
The present invention discloses a sulfur mixed anthracene compound photocatalytic oxidation synthesis method, sulfur mixed anthracene compound as a reaction substrate, in order to 2, 3 - dichloro - 5, 6 - dinitrile - 1, 4 - benzoquinone (DDQ) and tert-butyl nitrite (TBN) as catalyst, in order to acetic acid as the reaction additive, to oxygen as the oxidizing agent, the reaction substrate in 1, 2 - dichloroethane in the solvent, and the blue light illumination at normal temperature and under the conditions of reaction, after the reaction is completed after the separation and processed to obtain the sulfur mixed anthracene compound. The synthesizing method of the invention, in order to light the reaction to replace the traditional heating reaction, the energy can be saved; without the use of a transition metal catalyst; under the condition of optimizing, the yield is high. (by machine translation)
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Paragraph 0044-0045

(2019/02/04)

Method for catalytic oxidization synthesis of anthone compound
The invention discloses a method for catalytic oxidation synthesis of an anthone compound. The method is carried out according to the following steps: adding an anthene compound, Fe(NO3)3*9H2O and a fluorine-containing inorganic salt into an acetonitrile solvent, and performing a reaction for 2-12h at 75-85 DEG C under a normal pressure oxygen condition to obtain the anthone compound, wherein the mass ratio of the reaction substrate namely the anthone compound, Fe(NO3)3*9H2O and the fluorine-containing inorganic salt is 100:(8-15):(15-30), and after the completion of the reaction, the anthone compound can be obtained by adopting conventional column separation purification. The method provided by the invention is simple, convenient and safe to operate, and has the following beneficial effects: A) clean oxygen is used as an oxidant in the method, so that the environmental cost is greatly reduced; and B) Fe(NO3)3*9H2O is used as a catalyst in the method, so that the cost is low.
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Paragraph 0039

(2017/07/21)

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates
An efficient deborylthiolation of aryl- and alkenylborons with thiosulfonates has been achieved under mild conditions using a copper catalyst. All steps of the experimental process were free from unpleasant odors. The mild reaction conditions as well as ready availability of boron compounds and thiosulfonates enabled easy access to an array of sulfides, including those bearing sensitive functional groups.
Yoshida, Suguru,Sugimura, Yasuyuki,Hazama, Yuki,Nishiyama, Yoshitake,Yano, Takahisa,Shimizu, Shigeomi,Hosoya, Takamitsu
supporting information
p. 16613 - 16616
(2015/11/25)

A convenient synthesis of 9H-thioxanthen-9-ones and their aza-analogues
An efficient method for the preparation of 9H-thioxanthen-9-ones and their three aza-analogues has been developed. The reaction of (2-fluorophenyl)(2- halophenyl)methanones, derived from 1-bromo-2-fluorobenzenes and 2- halobenzaldehydes by an easy two-step sequence, with Na2S· 9H2O in DMF at 60 °C gives 9H-thioxanthen-9-ones. This procedure can be applied to the synthesis of 5H-[1]benzothiopyrano[2,3-b](or [2,3-c])pyridin-5-ones or 10H-[1]-benzothiopyrano[3,2-c]pyridin-10-ones starting from 2-, 3- or 4-chloropyridines, respectively.
Kobayashi, Kazuhiro,Komatsu, Toshihide,Nakagawa, Kazuhiro,Hara, Erika,Yuba, Shohei
p. 2577 - 2587
(2014/01/06)

O-acyloxime photoinitiators
Oximeester compounds of the formulae I, II, III and IV whereinR1 is phenyl, C1-C20alkyl or C2-C20alkyl optionally interrupted by —O—, C2-C20alkanoyl or benzoyl, or R1 is C2-C12alkoxycarbonyl or phenoxycarbonyl; R1′ is C2-C12alkoxycarbonyl, or R1′ is phenoxycarbonyl, or R1′ is —CONR10R11 or CN; R2 is C2-C12alkanoyl, C4-C6alkenoyl, benzoyl, C2-C6alkoxycarbonyl or phenoxycarbonyl; R3, R4, R5, R6 and R7 are hydrogen, halogen, C1-C12alkyl, cyclopentyl, cyclohexyl, phenyl, benzyl, benzoyl, C2-C12alkanoyl, C2-C12alkoxycarbonyl, phenoxycarbonyl or a group OR8, SR9, SOR9, SO2R9 or NR10R11; R4′, R5′ and R6′ are hydrogen, halogen, C1-C12alkyl, cyclopentyl, cyclohexyl, phenyl, benzyl, benzoyl, C2-C12-alkanoyl, C2-C12alkoxycarbonyl, phenoxycarbonyl, or are a group OR8, SR9, SOR9, SO2R9, NR10R11; provided that at least one of R3, R4, R5, R6, R7, R′4, R′5 and R′6 is OR8, SR9 or NR10R11; R8, R9, R10 and R11 are for example hydrogen, C1-C12alkyl, phenyl; are suitable as initiators for the photopolymerization of radically polymerizable compounds.
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(2008/06/13)

Process for the preparation of thioxanthones
Processes are described for the preparation of thioxanthones (Formula I). A reactant mixture of a 2-chlorothiobenzoyl chloride (Formula II) and an aromatic compound (Formula III) is added to a slurry of a Friedel-Crafts catalyst in an organic Friedel-Crafts solvent. Products of the processes may be used for the preparation of a pharmaceutical product for use in the field of psycho-therapeutics, or as activators or sensitizers in the photo-polymerization of ethylenically unsaturated monomers.
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Page 4

(2008/06/13)

Tricyclic psychotropic agents containing two chalcogen atoms in the central ring: 8-substituted 6-(4-piperidyl)-6H-dibenz[b,e]-1,4-oxathiepins
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Sindelar,Metysova,Holubek,et al.
p. 3077 - 3093
(2007/10/02)

Identification of 2-chlorothioxanthen-9-one in gastric aspirate in a case of chlorprothixene poisoning
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Pettersen,Teien,Ulsaker
p. 812 - 813
(2007/10/02)

Potential metabolites of the neuroleptic agent chlorprothixene; Synthesis and pharmacology of the 3-, 4-, 6- and 7-hydroxy and methoxy derivatives of 2-chloro-9-(3-dimethylaminopropylidene)-thioxanthenes
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Sindelar,Jilek,Korbl,et al.
p. 3166 - 3181
(2007/10/02)