The Biginelli reaction under batch and continuous flow conditions: Catalysis, mechanism and antitumoral activity
Two novel coordination polymers (CPs) have been synthesized, characterized and successfully applied as robust heterogeneous catalysts for the Biginelli multicomponent reaction to obtain 3,4-dihydropyrimidin-2(1H)-one or thione (DHPMs) derivatives. The rea
Silva, Gabriel C. O.,Correa, Jose R.,Rodrigues, Marcelo O.,Alvim, Haline G. O.,Guido, Bruna C.,Gatto, Claudia C.,Wanderley, Kaline A.,Fioramonte, Mariana,Gozzo, Fabio C.,De Souza, Rodrigo O. M. A.,Neto, Brenno A. D.
p. 48506 - 48515
(2015/06/16)
Ionic liquid effect over the biginelli reaction under homogeneous and heterogeneous catalysis
Bronsted and Lewis acid catalysts with ionic tags under homogeneous and heterogeneous conditions have been tested to perform the Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-one (DHPMs). Metal-containing ionic liquids were evaluated as the catalysts
Alvim, Haline G. O.,De Lima, Tatiani B.,De Oliveira, Heibbe C. B.,Gozzo, Fabio C.,De MacEdo, Julio L.,Abdelnur, Patricia V.,Silva, Wender A.,Neto, Brenno A. D.
p. 1420 - 1430
(2013/07/26)
The biginelli reaction with an imidazolium-tagged recyclable iron catalyst: Kinetics, mechanism, and antitumoral activity
The present work describes the synthesis, characterization, and application of a new ion-tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive performance. High yields have been achieved when the reaction was carried ou
Ramos, Luciana M.,Guido, Bruna C.,Nobrega, Catharine C.,Corrêa, José R.,Silva, Rafael G.,De Oliveira, Heibbe C. B.,Gomes, Alexandre F.,Gozzo, Fábio C.,Neto, Brenno A. D.
supporting information
p. 4156 - 4168
(2013/05/08)
Diphenylammonium triflate: A novel and efficient catalyst for synthesis of spiro-heterocyclic compounds
A general and practical one-pot synthesis of spiro-heterocyclic compounds using diphenylammonium triflate (DPAT, 5 mol%) as a novel and efficient catalyst is described. The pseudo four-components Biginelli-like reaction of 5,5- dimethyl-1,3-cyclohexanedione, thiourea and aldehydes catalyzed by DPAT in refluxing ethanol produced the corresponding spiro-heterocyclic compounds with moderate to good yields. A possible mechanism is proposed.
Li, Jianjun,Sun, Jian,Su, Weike
experimental part
p. 314 - 318
(2011/07/07)
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