- Synthesis of 2-fluorocholine aryl carbonyl compounds
-
The invention provides a method for synthesizing 2-fluoroarylcarbonyl compounds, which comprises the following steps: converting arylcarbonyl compounds into corresponding carbonyl oxime ether compounds, mildly implementing aryl hydrocarbon chain direct fluoridation of high-selectivity oximido substituent group ortho-position in the presence of a palladium catalyst, a fluoridation reagent and additives, and finally, rehydrolyzing oxime ethers under the action of acid to obtain the 2-fluoroarylcarbonyl compounds. The fluoridation method has the advantages of mild reaction conditions, high substrate adaptability, high fluoridation selectivity and the like, is simple to operate, and has higher application research value.
- -
-
Paragraph 0068; 0069; 0072
(2017/02/09)
-
- Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors
-
A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure-activity relationships at the 5- and 6-positions of the thienopyrimidine nucleus led to a series of N,N′-diaryl ureas that potentl
- Dai, Yujia,Guo, Yan,Frey, Robin R.,Ji, Zhiqin,Curtin, Michael L.,Ahmed, Asma A.,Albert, Daniel H.,Arnold, Lee,Arries, Shannon S.,Barlozzari, Teresa,Bauch, Joy L.,Bouska, Jennifer J.,Bousquet, Peter F.,Cunha, George A.,Glaser, Keith B.,Guo, Jun,Li, Junling,Marcotte, Patrick A.,Marsh, Kennan C.,Moskey, Maria D.,Pease, Lori J.,Stewart, Kent D.,Stoll, Vincent S.,Tapang, Paul,Wishart, Neil,Davidsen, Steven K.,Michaelides, Michael R.
-
p. 6066 - 6083
(2007/10/03)
-