cas 86801-04-9, 1-(3-Acetylphenyl)-2-thiourea | Articles data ｜lookchem

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86801-04-9

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Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases
Enteroviruses (EVs) are among the most frequent infectious agents in humans worldwide and represent the leading cause of upper respiratory tract infections. No drugs for the treatment of EV infections are currently available. Recent studies have also linked EV infection with pulmonary exacerbations, especially in cystic fibrosis (CF) patients, and the importance of this link is probably underestimated. The aim of this work was to develop a new class of multitarget agents active both as broad-spectrum antivirals and as correctors of the F508del-cystic fibrosis transmembrane conductance regulator (CFTR) folding defect responsible for >90% of CF cases. We report herein the discovery of the first small molecules able to simultaneously act as correctors of the F508del-CFTR folding defect and as broad-spectrum antivirals against a panel of EVs representative of all major species.
Tassini, Sabrina,Sun, Liang,Lanko, Kristina,Crespan, Emmanuele,Langron, Emily,Falchi, Federico,Kissova, Miroslava,Armijos-Rivera, Jorge I.,Delang, Leen,Mirabelli, Carmen,Neyts, Johan,Pieroni, Marco,Cavalli, Andrea,Costantino, Gabriele,Maga, Giovanni,Vergani, Paola,Leyssen, Pieter,Radi, Marco
p. 1400 - 1416
(2017/03/08)

Synthesis and antibacterial activity of 2-(3-acylphenyl)amino-4-phenylthiazole
Abstract 2-(3-acylphenyl)amino-4-phenylthiazoles were synthesized from 1-(3-acetylphenyl)thiourea and 2-bromo-1-substituted phenylethanones in presence of triethylamine upon heating. The newly synthesized compounds were characterized by IR, 1H
Subhashini,Amanaganti, Jampaiah,Shivaraj
p. 686 - 688
(2015/05/13)

HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT
Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent.
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Page/Page column 145

(2009/10/22)

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Chemical Properties

Melting Point: 165-167 °C
Boiling Point: 347.8 °C at 760 mmHg
Flash Point:164.1 °C
Density: 1.302 g/cm³
Vapor Pressure: 5.25E-05mmHg at 25°C
Refractive Index: 1.685
PKA: 12.54±0.70(Predicted)
PSA: 87.21000
LogP: 2.31800

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