Suzuki reactions with stable organic radicals - Synthesis of biphenyls substituted with nitronyl-nitroxide radicals
The synthesis of biphenyls substituted with nitronyl-nitroxide organic radicals is described. To investigate the Suzuki-type cross-coupling reaction conditions in the presence of the radical, a model compound 1 was prepared. The successful coupling was extended to cyano-functionalized, biphenylic, paramagnetic molecules. Both the ortho- and meta-iodophenyl-nitronyl-nitroxide radicals were used to synthesize radicals 2 and 3. The characterizations of the spin-labelled molecules obtained by this synthetic strategy include two X-ray crystal structures and magnetic measurements. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.