- Method for preparing beixifloxacin intermediate compound
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The invention provides a method for preparing a beixifloxacin intermediate compound VI. The method comprises the steps of: reacting a compound of a formula III with an upper protective group, an aminotransferase catalying and a deprotecting group to obtain a compound shown in a formula VI. The method can be used for preparing the beixifloxacin intermediate compound VI rapidly and effectively. Rawmaterials are simple and easy to obtain, the reaction is simple and easy to operate, harsh reaction conditions are not required, a production period is short, yield of a target product is high, separation and purification of the target product are simple, optical purity is high, the method is easy to achieve mass production.
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- BTK INHIBITOR
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Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
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Paragraph 1043-1044
(2017/11/16)
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- AZOCANE AND AZONANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
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Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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Paragraph 0298; 0303; 0304
(2016/10/11)
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- Iridium-catalyzed X-H insertions of sulfoxonium ylides
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Image Persented The unique reactivity of sulfoxonium ylides as a carbene source is described for a variety of X-H bond insertions, taking advantage of a simple, commercially available iridium catalyst. This method has applications in both intra- and intermolecular reactivity, including a practical ring-expansion strategy for lactams. The safety and stability of sulfoxonium ylides recommend them as preferable surrogates to traditional diazo ketones and esters.
- Mangion, Ian K.,Nwamba, Ikenna K.,Shevlin, Michael,Huffman, Mark A.
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supporting information; experimental part
p. 3566 - 3569
(2011/02/22)
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