Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin- 1-yl}methyl)quinoxaline(WAY-207024): An orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R)
A potent, highly insoluble, GnRH antagonist with a 2-phenyl-4- piperazinylbenzimidazole template and a quinoxaline-2,3-dione pharmacophore was modified to maintain GnRH antagonist activity and improve in vitro pharmaceutical properties. Structural changes
Pelletier, Jeffrey C.,Chengalvala, Murty V.,Cottom, Joshua E.,Feingold, Irene B.,Green, Daniel M.,Hauze, Diane B.,Huselton, Christine A.,Jetter, James W.,Kopf, Gregory S.,Lundquist, Joseph T.,Magolda, Ronald L.,Mann, Charles W.,Mehlmann, John F.,Rogers, John F.,Shanno, Linda K.,Adams, William R.,Tio, Cesario O.,Wrobel, Jay E.
The present invention relates to Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
-
Page/Page column 36
(2010/02/15)
Processes for preparing gonadotropin releasing hormone receptor antagonists
The present invention relates to methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
-
Page/Page column 18
(2008/06/13)
More Articles about upstream products of 872002-72-7