Cumulated Ylides XX. Syntheses of (E)-α,β-Unsaturated Macrocyclic Lactones by Intramolecular Wittig-Olefination via Triphenylphosphoranylideneketene
Two methods for closure of macrocyclic lactone rings by intramolecular Wittig reaction of (ω-oxoalkoxy)carbonylmethylenetriphenylphosphoranes are described.The latter are easily accessible by addition of the appropriate (free or protected) ω-hydroxyalkanals to the cumulated ylide triphenylphosphoranylideneketene.Examples are then given for the use of these methods in natural product synthesis.
Bestmann, Hans Juergen,Schobert, Rainer
p. 419 - 423
(2007/10/02)
Neue Synthese makrocyclischer Lactone
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Bestmann, Hans Juergen,Schobert, Rainer
p. 810 - 811
(2007/10/02)
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