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87240-07-1

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NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in comb
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Paragraph 0237; 0240-0241

(2014/06/11)

NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1 ), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight management therapies or other triglyceride lowering therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit.
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Page/Page column 50

(2014/06/11)

SPECIFICALLY DEUTERATED AND TRITIATED AUXINS
Regiospecific synthesis of monodeuterated and monotritiated natural auxin (indole-3-acetic acid), a synthetic auxin (naphthalene-1-acetic acid) and a photoaffinity labeling auxin (5-azidoindole-3-acetic acid) are described.These synthesis provide benzene-ring tritiated auxins for use in reversible and covalent binding studies. - Key Word Index: Auxin; azido auxin; indole-3-acetic acid; 5-azidoindole-3-acetic acid; napthalene-1-acetic acid; radiolabeling; photoaffinity labeling; synthesis.
Melhado, L. Lee,Pearce, Cedric J.,d'Alarcao, Marc,Leonard, Nelson J.
p. 2879 - 2886
(2007/10/02)

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5192-03-0
5-amino-1H-indole

Chemical Properties

Boiling Point: 402.3 °C at 760 mmHg
Flash Point:197.1 °C
Density: 1.855 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 2.57E-06mmHg at 25°C
Refractive Index: 1.747
PKA: 13.58±0.30(Predicted)
PSA: 61.61000
LogP: 3.36180

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