Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H- pyrimidine-2,4-diones
A stepwise synthetic approach involving substitution of 6-chloro-1,3-dialkyluracils (5 and 6) with 3-(tert-amino)-2-hydroxypropylamines and subsequent acylation at C5 of uracil has been used to synthesize pyrimidinediones 27-33 in 61-89% overall yield. Th
Singh, Palwinder,Paul, Kamaldeep,Holzer, Wolfgang
p. 3959 - 3965
(2007/10/03)
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