- CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
-
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
- -
-
Paragraph 1405
(2018/04/17)
-
- IMIDAZOPYRAZINONE DERIVATIVES
-
Compounds of the formula (I) in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nerv
- -
-
Page/Page column 45
(2015/07/15)
-
- LXR MODULATORS
-
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.
- -
-
Page/Page column 185-186
(2014/09/29)
-
- SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
-
Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
- -
-
Page/Page column 314
(2009/03/07)
-
- Synthesis and biological activity of 2-methyl-and 2-bromomethylimidazole nucleosides (1)
-
The nucleosides of ethyl 2-methylimidazole-4(5)-carboxylate and 2-methylimidazole 4(5)-carboxamide were synthesized by the mercuric cyanide method. The acetylated 2-methyl-4-carboxylate substituted glucoside was also obtained by reductive deamination of the corresponding 5-amino nucleoside derivative. The acetylated 2-methyl-4-carboxylate substituted nucleosides were treated with N-bromosuccinimide to give the corresponding 2-bromomethyl derivatives which showed significant activity gainst HeLa cell cultures. Structural assignments were made on the bases of H 1NMR spectra and, in the some cases, were confirmed by chemical evidence. Nucleosides of 2-methylimidazole-4-carboxamide were tested against type 1 herpes simplex virus and all of them were inactive. The cytostatic activity of the 2-bromomethyl-4-carboxylate substituted nucleosides and the fact that the 2-methyl group of 1-β-D-ribofuranosylimidazole-2-methyl-4-carboxamide causes the loss of antiviral activity are discussed.
- Garcia-Lopez,Herranz,Andres
-
p. 187 - 191
(2007/10/02)
-