cas 874479-16-0, (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile | Articles data ｜lookchem

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874479-16-0

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Synthesis of thiophene analogues of the tacrine series
3-Amino-2-cyanothiophenes condensed with cyclanones and afforded analogues of Velnacrine in two or three steps. Condensation under Friedlander's conditions gave tacrine analogues in one step. Georg Thieme Verlag Stuttgart.
Thomae, David,Kirsch, Gilbert,Seck, Pierre
p. 1027 - 1032
(2008/02/02)

Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
2-(3′,4′,5′-Trimethoxybenzoyl)-3-amino-5-aryl/heteroaryl thiophene derivatives were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. SARs were elucidated with various substitutions on
Romagnoli, Romeo,Baraldi, Pier Giovanni,Remusat, Vincent,Carrion, Maria Dora,Lopez Cara, Carlota,Preti, Delia,Fruttarolo, Francesca,Pavani, Maria Giovanna,Aghazadeh Tabrizi, Mojgan,Tolomeo, Manlio,Grimaudo, Stefania,Balzarini, Jan,Jordan, Mary Ann,Hamel, Ernest
p. 6425 - 6428
(2007/10/03)

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B
Reversible phosphorylation and dephosphorylation of key proteins on tyrosine residues are important parts of intracellular signaling triggered by hormones and other agents. Recent knock-out studies in mice have identified PTP1B as a potential target for t
Andersen, Henrik Sune,Olsen, Ole H.,Iversen, Lars F.,S?rensen, Anette L. P.,Mortensen, Steen B.,Christensen, Michael S.,Branner, Sven,Hansen, Thomas K.,Lau, Jesper F.,Jeppesen, Lone,Moran, Edmond J.,Su, Jing,Bakir, Farid,Judge, Luke,Shahbaz, Manou,Collins, Tassie,Vo, Todd,Newman, Michael J.,Ripka, William C.,M?ller, Niels Peter H.
p. 4443 - 4459
(2007/10/03)

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Chemical Properties

Boiling Point: 335℃
Flash Point:157℃
Density: 1.191
Storage Temp.:2-8°C
PSA: 33.02000
LogP: 2.79848

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