- Synthesis and antitumor activity of Pt(II) complexes containing 2,3-diaminopropanol isomers
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Halogeno, sulfato, and nitrato Pt(II) complexes of 2,3-diaminopropranolol (pnOH) isomers were synthesized and their activities against leukemia L1210 were tested. The conformations of their chelate rings were determined to be λ- and δ-gauche forms for R- and S-pnOH, respectively, by 13C-nuclear magnetic resonance and circular dichroism spectral analyses. Among the pnOH isomers, Pt(II) complexes containing R-pnOH showed higher antitumor activity than those containing S- or racemic pnOH. It seems that there may be a relationship between the conformations of the chelate rings and antitumor activity in the case of five-membered chelate rings.
- Noji,Motoama,Tashiro,Kidani
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