- Synthesis method of vitamin D analogue intermediate
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The invention discloses a synthesis method of a vitamin D analogue intermediate, and discloses a photochemical reaction method for preparing a revere intermediate (II) from a cis-form initiator (I). The intermediate prepared through the method can serve a
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Paragraph 0033; 0035
(2019/10/01)
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- Efficient convergent synthesis of 1alpha,25-dihydroxyvitamin D3 and its analogues by Suzuki-Miyaura coupling.
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[reaction: see text] 1alpha,25-Dihydroxyvitamin D(3) was synthesized by the Suzuki-Miyaura coupling of the A-ring intermediate 1, which was efficiently prepared from readily available 1,7-enyne 2, with the corresponding boronate compound of the C,D-ring portion. The method was applied to prepare des-C,D analogues of 1alpha,25-dihydroxyvitamin D(3).
- Hanazawa, Takeshi,Koyama, Akiko,Wada, Takeshi,Morishige, Eiko,Okamoto, Sentaro,Sato, Fumie
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p. 523 - 525
(2007/10/03)
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- A Novel Approach to the Stereocontrolled Synthesis of Steroid Side Chains Including the CD-Ring System: The First Total Synthesis of (+)-8α-(Phenylsulfonyl)des-AB-cholestane and Its Efficient Conversion into Grundmann's Ketone and Vitamin D3
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A new stereocontrolled approach to steroid CD-ring system including side chain starting from an optically active indenedione 6 is described.The application of this finding allows for the asymmetric synthesis of des-AB-cholestane 3 and 8α-(phenylsulfonyl)des-AB-cholestane 37; from the latter Grundmann's ketone 25 and vitamin D3 (27) were synthesized efficiently.
- Nemoto, Hideo,Kurobe, Hiroshi,Fukumoto, Keiichiro,Kametani, Tetsuji
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p. 5311 - 5320
(2007/10/02)
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- A MODIFIED SYNTHESIS OF THE (+)-8α-PHENYLSULPHONYL-DES-AB-CHOLESTANE VIA AN INTRAMOLECULAR NUCLEOPHILIC ATTACK TO EPOXIDE - A TOTAL SYNTHESIS OF VITAMIN D3
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An intramolecular alkylation of the phenylsulphonyl epoxide (6), which was readily obtained from the alsehyde (5), gave a separable mixture of the alcohols (7a) and (8a).The alcohol (8a) was then dehydrated via the corresponding mesylate (8b) to afford th
- Nemoto, Hideo,Kurobe, Hiroshi,Fukumoto, Keiichiro,Kametani, Tetsuji
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p. 567 - 569
(2007/10/02)
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