Anthracene-rhodium complexes with metal coordination at the central ring-a new class of catalysts for reductive amination
A new class of anthracene complexes with a metal coordinated at the central ring was applied in catalysis for the first time. As a result, a simple and efficient protocol for reductive amination that involves CO as a reducing agent has been developed. The rhodium complex [(cyclooctadiene)Rh(C10H4Me2(OMe)4)]+ (1 mol%) catalyses such reactions under mild conditions (40-130 °C) and produces a variety of amines in good yields (74-95%) without affecting the functional groups. The protocol is acceptable for all combinations of aldehydes (aromatic and aliphatic), ketones (aromatic and aliphatic) and amines (aromatic and aliphatic; primary and secondary).
Ruthenium-catalyzed reductive amination without an external hydrogen source
A ruthenium-catalyzed reductive amination without an external hydrogen source has been developed using carbon monoxide as the reductant and ruthenium(III) chloride (0.008-2 mol %) as the catalyst. The method was applied to the synthesis of antianxiety agent ladasten.
Kolesnikov, Pavel N.,Yagafarov, Niyaz Z.,Usanov, Dmitry L.,Maleev, Victor I.,Chusov, Denis
supporting information
p. 173 - 175
(2015/01/30)
Palladium-catalyzed amination of isomeric dihalobenzenes with 1- and 2-aminoadamantanes
Palladium-catalyzed amination of isomeric bromochloro- and dibromobenzenes with 1- and 2-aminoadamantanes was studied. The best yields of the corresponding monoamination products were obtained in the reactions of 2-aminoadamantane with bromochlorobenzenes