Discovery of new selective glucocorticoid receptor agonist leads
We report on the discovery of two new lead series for the development of glucocorticoid receptor agonists. Firstly, the discovery of tetrahydronaphthalenes led to metabolically stable and dissociated compounds. Their binding mode to the glucocorticoid rec
Berger, Markus,Rehwinkel, Hartmut,Schmees, Norbert,Sch?cke, Heike,Edman, Karl,Wissler, Lisa,Reichel, Andreas,Jaroch, Stefan
Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
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Page/Page column 10-11
(2008/12/04)
Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents
The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.
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Page/Page column 20
(2010/11/28)
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