Stereoselective Z- and E-Bromo Enol Lactonization of Alkynoic Acids
We have found that treatment of the silver salt of a 4- or 5-terminal alkynoic acid with bromine results in clean formation of the corresponding Z-bromo enol lactone, the result of a formal cis addition of carboxylate and bromine across the triple bond.Th
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer
Haloenol pyran-2-ones and morpholin-2-ones were synthesized and evaluated as inhibitors of cell growth in two different prostate human cancer cell lines (PC-3 and LNCaP). Analogs derived from l- and d-phenylglycine were found to be the most effective antagonists of LNCaP and PC-3 cell growth. Additional studies reveal that the inhibitors induced G2/M arrest and the (S)-enantiomer of the phenylglycine-based derivatives was a more potent inhibitor of cytosolic iPLA2β.
Mock, Jason N.,Taliaferro, John P.,Lu, Xiao,Patel, Sravan Kumar,Cummings, Brian S.,Long, Timothy E.
scheme or table
p. 4854 - 4858
(2012/08/13)
METHOD OF SELECTIVELY INHIBITING CALCIUM-INDEPENDENT MYOCARDIAL PHOSPHOLIPASE A2
Inhibition of calcium-independent myocardial phospholipase A2 is shown for compounds of the formula: wherein R and R1 independently represent hydrogen and halogen, alkyl, alkenyl and alkynyl radicals; R2 represents aryl, aryloxy, and heteroaryl radicals; and X is 1 or 2
-
(2008/06/13)
More Articles about upstream products of 88070-96-6