Synthesis and antihyperlipidemic activity of some novel condensed 2-chloroalkyl-4-chloro/hydroxy-5,6-disubstituted pyrimidines
Synthesis and antihyperlipidemic activity of a series of novel condensed 2-chloroalkyl-4-chloro/hydroxy-5,6-di-substituted pyrimidines are described. The design of these compounds is based on the earlier QSAR study on the antihyperlipidemic 2-substituted
Reaction of Nitriles under Acidic Conditions. Part VI. Synthesis of Condensed 4-Chloro- and 4-Aminopyrimidines from ortho-Aminonitriles
Condensation of a nitrile with benzene, furan and thiophene ortho-aminonitriles in the presence of dry hydrogen chloride yields condensed 4-chloropyrimidines, condensed 4-aminopyrimidines or a mixture of the two condensed pyrimidines in varying proportions depending upon the nature of the nitrile and the substrate, ortho-aminonitrile.
Shishoo, C. J.,Devani, M. B.,Bhadti, V. S,Jain, K. S.,Ananthan, S.
p. 119 - 126
(2007/10/02)
REACTION OF NITRILES UNDER ACIDIC CONDITIONS: A NOVEL, DIRECT FORMATION OF CONDENSED 4-CHLOROPYRIMIDINES
An unusual formation of condensed 4-chloropyrimidines in the reaction of o-aminonitriles with halogenoacetonitriles in the presence of dry hydrogen chloride gas is described.
Shishoo, C. J.,Devani, M. B.,Bhadti, V. S.,Anathan, S.,Ullas, G. V.
p. 4611 - 4612
(2007/10/02)
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