Synthesis and activity of small molecule GPR40 agonists
The first report on the identification and structure-activity relationships of a novel series of GPR40 agonists based on a 3-(4-{[N-alkyl]amino}phenyl) propanoic acid template is described. Structural modifications to the original screening hit yielded co
Garrido, Dulce M.,Corbett, David F.,Dwornik, Kate A.,Goetz, Aaron S.,Littleton, Thomas R.,McKeown, Steve C.,Mills, Wendy Y.,Smalley Jr., Terrence L.,Briscoe, Celia P.,Peat, Andrew J.