Hypoxia-activated prodrugs: Substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents
Nitrochloromethylbenzindolines (nitroCBIs) are a new class of hypoxia-activated prodrugs for antitumor therapy. The recently reported prototypes undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents and are selectively tox
Tercel, Moana,Atwell, Graham J.,Yang, Shangjin,Stevenson, Ralph J.,Botting, K. Jane,Boyd, Maruta,Smith, Eileen,Anderson, Robert F.,Denny, William A.,Wilson, William R.,Pruijn, Frederik B.
supporting information; experimental part
p. 7258 - 7272
(2010/07/13)
NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY
The present invention relates generally to nitro-1,2-dihydro-3H-benzo[e]indoles and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation a
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Page/Page column 95-99
(2010/11/08)
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