Synthesis of diverse β-quaternary ketones via palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enones
Abstract The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enone conjugate acceptors is described. These reactions employ air-stable and readily-available reagents in an operationally si
Holder, Jeffrey C.,Goodman, Emmett D.,Kikushima, Kotaro,Gatti, Michele,Marziale, Alexander N.,Stoltz, Brian M.
p. 5781 - 5792
(2015/08/03)
Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF3)2 and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).
Holder, Jeffrey C.,Marziale, Alexander N.,Gatti, Michele,Mao, Bin,Stoltz, Brian M.
supporting information
p. 74 - 77
(2013/02/25)
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