cas 89380-77-8, Methyl 3-hydroxy-5-nitro-2-thiophenecarboxylate | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
89380-77-8

Articles about 89380-77-8Total 3 be found

Article title
Article abstract
Author
Journal number and time
Download

Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene a-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship
We describe herein the structure-activity relationship (SAR) and cocrystal structures of a series of Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1. Our studies reveal a nonlinear SAR for Nek2 and our cocrystal structures show that compounds in this series bind to a DFG-out conformation of Nek2 without extending into the enlarged back pocket commonly found in this conformation. These observations were further investigated, and structure-based design led to Nek2 inhibitors derived from (R)-1 with more than a hundred-fold selectivity against Plk1.
Solanki, Savade,Innocenti, Paolo,Mas-Droux, Corine,Boxall, Kathy,Barillari, Caterina,Van Montfort, Rob L. M.,Aherne, G. Wynne,Bayliss, Richard,Hoelder, Swen
supporting information; experimental part
p. 1626 - 1639
(2011/06/17)

Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres
Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buckwald
Chao, Jianhua,Taveras, Arthur G.,Aki, Cynthia J.
scheme or table
p. 5005 - 5008
(2009/12/01)

Nitration of Methyl 3-Hydroxy- and 5-methyl-3-hydroxythipophene-2-carboxylate, and Some Chemistry of the Products
The nitration of methyl 3-hydroxythiophene-2-carboxylate furnishes two products, the lower melting of which was previously thought to be the 4-(3) and the other the 5-isomer (2); these assignments have been reversed on the basis of carbon-13 n.m.r. data. Further, the revised structures were confirmed both by O to N acyl migrations and by the preparation of the first examples (20) and (23) of the thieno[3,4-b][1,4]oxazine ring system from derivatives of the 4-nitro isomer.
Barker, John M.,Huddelston, Patrick R.,Wood, Michael L.,Burkitt, Simon A.
p. 1001 - 1023
(2007/10/03)

More Articles about upstream products of 89380-77-8

5118-06-9
methyl 3-hydroxy-2-thiophenecarboxylate

More Articles about downstream products of 89380-77-8

Chemical Properties

Boiling Point: 329.379 °C at 760 mmHg
Flash Point:153.003 °C
Density: 1.599 g/cm³
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.623
PSA: 120.59000
LogP: 1.67170

Show more

Global suppliers and manufacturers of 89380-77-8total 28 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:994
Country:

Hangzhou J&H Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:46
Country:

Hangzhou Huarong Pharm Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:65
Country:

Bluecrystal chem-union
Business Type:Trading Company
Min Order:1 Metric Ton
FOB Price:USD $ 1.0-1.0 / Metric Ton
Main Products:7
Country:

GIHI CHEMICALS CO.,LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:80
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Henan Tianfu Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:67
Country:

BOC Sciences
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:41
Country:

Hangzhou Fandachem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:52
Country:

Hangzhou Sartort Biopharma Co., Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:80
Country:

SAGECHEM LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:33
Country:

Hunan Longxianng Runhui Trading Co.,Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:38
Country:

Chemlyte Solutions
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:198
Country:

AstaTech ( Chengdu) BioPharmaceutical Corp.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:43
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

Bide Pharmatech Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

HENAN SUNLAKE ENTERPRISE CORPORATION
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:No Data
Main Products:1
Country:

ENAO Chemical Co, Limited
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Shanghai Hanhong Scientific Co.,Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 89380-77-8

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer