Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs
In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure features and fitted with functional groups believed to enhance inhibition of mammalian DHFR activity. M
Al-Rashood, Sarah T.,Aboldahab, Ihsan A.,Nagi, Mahmoud N.,Abouzeid, Laila A.,Abdel-Aziz, Alaa A.M.,Abdel-hamide, Sami G.,Youssef, Khairia M.,Al-Obaid, Abdulrahman M.,El-Subbagh, Hussein I.
p. 8608 - 8621
(2008/02/05)
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