Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by
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Page/Page column 12
(2008/06/13)
EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS
The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught her
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Page/Page column 35-37
(2008/06/13)
PREPARATION OF CHIRAL PROPARGYLIC ALCOHOL AND ESTER INTERMEDIATES OF HIMBACINE ANALOGS
This application discloses a novel process for the conversion of a series of racemic propargylic alcohols to corresponding (R)-enantiomers. The application also discloses the enantio-selective esterification of a propargylic alcohol from its racemate to p
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Page/Page column 42-44
(2008/06/13)
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