Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel
Shorter than ever: A convergent, efficient, and scalable access based on a key Ugi four-component reaction (4CR) followed by a Pictet-Spengler reaction comprises the shortest known synthesis to the schistosomiasis drug praziquantel (see scheme).
Cao, Haiping,Liu, Haixia,Doemling, Alexander
experimental part
p. 12296 - 12298
(2011/02/25)
Synthesis of praziquantel via N-acyliminium ion cyclization of amtoo acetals through several synthetic routes
Syntheses of praziquantel have been accomplished via an N-acyliminium ion by several routes including the tandem nucleophilic addition-cyclization sequence from amido acetal (8) or (10) and a stepwise cyclization of enamide (9) generated from the nucleophilic addition reaction of amido acetal (8) or (10).
Kim, Joong Hyup,Lee, Yong Sup,Kim, Choong Sup
p. 2279 - 2285
(2007/10/03)
More Articles about upstream products of 90142-13-5