- 7,5′-O-dibenzylinosines: Synthesis and studies on their conformational properties
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Reaction of 2′,3′-O-isopropylidene inosine with benzyl bromide (1 h, rt) led to the 1,5′-O-dibenzylderivative 4, but by increasing the reaction time or the temperature, compound 4 is further transformed into the 1,7,5′-O-tribenzylinosine derivative 5. Sim
- Casanova, Elena,Aguado, Leire,Jimeno, Maria-Luisa,Gago, Federico,Camarasa, Maria-Jose,Perez-Perez, Maria-Jesus
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- Intramolecular cation-π interactions as the driving force to restrict the conformation of certain nucleosides
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"Chemical Equation Presented" Despite the well-established importance of intermolecular cation-π interactions in molecular recognition, intramolecular cation-jr interactions have been less studied. Here we describe how the simultaneous presence of an arom
- Casanova, Elena,Priego, Eva-Maria,Jimeno, Maria-Luisa,Aguado, Leire,Negri, Ana,Gago, Federico,Camarasa, Maria-Jose,Perez, Maria-Jesus
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scheme or table
p. 1974 - 1981
(2010/05/19)
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- 5′-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase
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On the basis of our previous findings that 5′-O-tritylinosine (KIN59) behaves as an allosteric inhibitor of the angiogenic enzyme thymidine phosphorylase (TPase), we have undertaken the synthesis and enzymatic evaluation of a novel series of nucleoside an
- Casanova, Elena,Hernández, Ana-Isabel,Priego, Eva-María,Liekens, Sandra,Camarasa, María-José,Balzarini, Jan,Pérez-Pérez, María-Jesús
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p. 5562 - 5570
(2007/10/03)
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