- Benzodiazepine-receptor (BZR) Ligands: the Conformational Fit of Agonist &β-Carbolines to an Imidazobenzodiazepine Template
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This work describes the rationale for the design and synthesis as well as the in vitro biological evaluation of three novel analogs of ethyl 6-benzyloxy-4-methoxymethyl-β-carboline-3-carboxylate (ZK93423), a BZR agonist ligand. Previous computer graphics
- Fryer, R. Ian,Wang, C.-G.,Chia, N.-C.,Basile, A. S.,Gu, Z.-Q.,Skolnick, P.
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p. 296 - 307
(2007/10/03)
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- Structural requirements for agonist actions at the benzodiazepine receptor: Studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester
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The analogues 2, 3, 8a-c, 9, 13, and 14 of the β-carboline 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK-93423, 1) were synthesized in order to determine which functional groups are required for agonist activity exhibited b
- Hollinshead,Trudell,Skolnick,Cook
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p. 1062 - 1069
(2007/10/02)
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