Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.
Dropinski, James F.,Akiyama, Taro,Einstein, Monica,Habulihaz, Bahanu,Doebber, Tom,Berger, Joel P.,Meinke, Peter T.,Shi, Guo Q.
p. 5035 - 5038
(2007/10/03)
More Articles about upstream products of 911818-14-9