Synthesis of γ-hydroxybutenolides applying crossed aldol condensation in the presence of a bulky Lewis acid and their anti-tumor activity
An improved synthesis of γ-hydroxybutenolides 1a - d was achieved via crossed aldol condensation between aldehydes 2a - d and the protected γ-hydroxy-β-methylbutenolides 3 or 4 using the bulky Lewis acid, aluminum tris(2,6-diphenylphenoxide) (ATPH). Using this same methodology, the γ-hydroxybutenolides 17a - d having various heteroaromatic rings were synthesized and their anti-tumor activities were evaluated.
A novel and useful method for treating and/or preventing ulcer in human beings is provided which comprises administering an effective amount of a pharmaceutical composition comprising at least one of the conjugated γ-oxybutenolide compounds represented by
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(2008/06/13)
Synthesis and Spectral Characterization of γ-Hydroxy-Δα,β-butenolides Possessing a Conjugated Substituent at the β-Position
Conjugated γ-hydroxybutenolides (6a-h, 10, and 11) were synthesized in three steps starting from various aldehydes (3a-h and 7), and their spectral characteristics were compared with those of unconjugated butenolides (12 and 13).Keywords-conjugated γ-hydr
Ito, Masayoshi,Iwata, Tsutomu,Tsukida, Kiyoshi
p. 4346 - 4351
(2007/10/02)
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