Ru-catalyzed highly enantioselective hydrogenation of α-keto Weinreb amides
Asymmetric hydrogenation of α-keto Weinreb amides has been realized with [Ru((S)-Sunphos)(benzene)Cl]Cl as the catalyst and CeCl3· 7H2O as the additive. A series of enantiopure α-hydroxy Weinreb amides (up to 97% ee) have been obtained. Catalytic amount of CeCl 3·7H2O is essential for the high reactivity and enantioselectivity and the ratio of CeCl3·7H2O to [Ru((S)-Sunphos)(benzene)Cl]Cl plays an important role in the hydrogenation reaction.
New methodology for the synthesis of α,α-difluoroketones
A new methodology is described for the synthesis of α,α- difluorinated ketones by the addition of organolithium reagents to α,α-difluoro-N-methoxy-N-methyl amides (Weinreb amides). Copyright Taylor & Francis Group, LLC.
Biju, Purakkattle
p. 1940 - 1945
(2008/09/20)
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