Reductive amination/cyclization of ω-trifluoromethyl keto esters to trifluoromethylated δ-amino alcohols and lactams
A reductive amination/cyclization approach towards biologically interesting trifluoromethylated four- to seven-membered ring lactams from simply prepared ω-trifluoromethyl keto esters in good to excellent yields has been developed. In addition, trifluorom